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apalutamide will lessen the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medication which are CYP3A4 substrates may end up in decrease publicity to those prescription drugs.nelfinavir will raise the stage or impact